Evaluation of the Antioxidant Interactions Between Green Tea Polyphenols and Nonsteroidal Anti-inflammatory Drugs

Aleksandra Sentkowska1, Krystyna Pyrzynska2
1 University of Warsaw, Heavy Ion Laboratory, Pasteura 5A, 02-093Warsaw, Poland
2 University of Warsaw, Department of Chemistry, Pasteura 1, 02-093Warsaw, Poland



The antioxidant interactions between the commonly used pharmaceuticals (diclofenac, ibuprofen and naproxen) and green tea polyphenols were evaluated.


The antioxidant properties of the mixtures were evaluated by a scavenging effect on the 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical.


The mixtures contained green tea extract and each drug exhibited lower antioxidant activity than the mathematical sum of the results obtained for individual components showing antagonistic effect. The results were obtained using isobolographic analysis and interaction factors also suggested the antagonistic type of interaction. Only when the concentration of the green tea infusion was relatively high (in comparison to the drug), an additive effect could be concluded.


The high concentration of green tea infusion in comparison to the drug should be used in developing the new formulations as it can help in the therapy due to their antioxidant properties.

Keywords: Green tea polyphenols, Nonsteroidal anti-inflammatory drugs, Isobolographic analysis, Interaction factor.

Abstract Information

Identifiers and Pagination:

Year: 2019
Volume: 6
Publisher Item Identifier: EA-CHEM-2019-14

Article History:

Received Date: 08/07/2018
Revision Received Date: 27/09/2018
Acceptance Date: 01/10/2019
Electronic publication date: 25/10/2019
Collection year: 2019

© 2019 Sentkowska and Pyrzynska

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at University of Warsaw, Department of Chemistry, Pasteura 1, 02-093 Warsaw, Poland;
E-mail: kryspyrz@chem.uw.edu.pl