REVIEW ARTICLE


Michael Addition of Imidazole to α, β -Unsaturated Carbonyl/Cyano Compound



Seetaram Mohapatra*, Nilofar Baral, Nilima Priyadarsini Mishra, Pravati Panda, Sabita Nayak
Organic Synthesis Laboratory, Department of Chemistry, Ravenshaw University, Cuttack-753 003, Odisha, India


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© 2018 Mohapatra et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Organic Synthesis Laboratory, Department of Chemistry, Ravenshaw University, Cuttack-753 003, Odisha, India, Tel: 7735675772; E-mail: seetaram.mohapatra@gmail.com


Abstract

Introduction:

Aza-Michael addition is an important reaction for carbon-nitrogen bond formation in synthetic organic chemistry.

Expalantion:

Conjugate addition of imidazole to α,β-unsaturated carbonyl/cyano compounds provides significant numbers of the biologically and synthetically interesting products, such as β-amino acids and β-lactams, which have attracted great attention for their use as key intermediates of anticancer agents, antibiotics and other drugs.

Conclusion:

This review addresses most significant method for the synthesis of N-substituted imidazole derivatives following Michael addition reaction of imidazole to α,β-unsaturated carbonyl/cyano compounds using ionic liquid/base/acid/enzyme as catalysts from year 2007-2017.

Keywords: Michael addition, Imidazole derivative, Methyl acrylate, Silica sulfuric acid, Heterocycles, Ionic liquids.