Michael Addition of Imidazole to α, β -Unsaturated Carbonyl/Cyano Compound
Seetaram Mohapatra*, Nilofar Baral, Nilima Priyadarsini Mishra, Pravati Panda, Sabita Nayak
Identifiers and Pagination:Year: 2018
First Page: 18
Last Page: 31
Publisher Id: CHEM-5-18
Article History:Received Date: 17/12/2017
Revision Received Date: 25/02/2018
Acceptance Date: 27/03/2018
Electronic publication date: 30/04/2018
Collection year: 2018
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Aza-Michael addition is an important reaction for carbon-nitrogen bond formation in synthetic organic chemistry.
Conjugate addition of imidazole to α,β-unsaturated carbonyl/cyano compounds provides significant numbers of the biologically and synthetically interesting products, such as β-amino acids and β-lactams, which have attracted great attention for their use as key intermediates of anticancer agents, antibiotics and other drugs.
This review addresses most significant method for the synthesis of N-substituted imidazole derivatives following Michael addition reaction of imidazole to α,β-unsaturated carbonyl/cyano compounds using ionic liquid/base/acid/enzyme as catalysts from year 2007-2017.