Synthesis and In-vitro Antifungal Evaluation of 5- Pyrazolones Alternate Title: Synthesis and In-vitro Antifungal Evaluation of 5- Pyrazolones



Poonam Gupta*, Jitendra K. Gupta
School of Studies in Chemistry, Jiwaji University Gwalior, India.


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© Gupta and Gupta; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the (https://creativecommons.org/licenses/by/4.0/legalcode), which permits unrestricted, noncommercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Research Scholar Jiwaji University, Gwalior, India; Tel: 9039926286; E-mail: poonamgupta_001@yahoo.com


Abstract

A series of 4-chloro-3-methyl-N-(substituted phenyl)-5-oxo-4,5-dihydro-1H-pyrazole-1- carbothioamide were synthesized using earmark reaction of thiosemicarbazides and ethyl-2-chloroacetoacetate in DMF. All structures of the synthesized compounds were distinguished on the basis of IR, 1H-NMR, 13C-NMR and also elemental analysis. Synthesized Compounds were examined their potent antifungal activity using disc diffusion technique against three fungal pathogens viz Aspergillus niger, Candida albicans and Curvularia. Fluconazole were used as standard drug respectively. All compounds exhibited good to moderate activity.

Keywords: Antifungal activity, disc diffusion technique, pyrazolones, thiosemicarbazides.