Synthesis and In-vitro Antifungal Evaluation of 5- Pyrazolones Alternate Title: Synthesis and In-vitro Antifungal Evaluation of 5- Pyrazolones
Poonam Gupta*, Jitendra K. Gupta
Identifiers and Pagination:Year: 2016
First Page: 17
Last Page: 24
Publisher Id: CHEM-3-17
Article History:Received Date: 09/04/2015
Revision Received Date: 27/7/2015
Acceptance Date: 9/10/2015
Electronic publication date: 09/05/2016
open-access license: This is an open access article licensed under the terms of the (https://creativecommons.org/licenses/by/4.0/legalcode), which permits unrestricted, noncommercial use, distribution and reproduction in any medium, provided the work is properly cited.
A series of 4-chloro-3-methyl-N-(substituted phenyl)-5-oxo-4,5-dihydro-1H-pyrazole-1- carbothioamide were synthesized using earmark reaction of thiosemicarbazides and ethyl-2-chloroacetoacetate in DMF. All structures of the synthesized compounds were distinguished on the basis of IR, 1H-NMR, 13C-NMR and also elemental analysis. Synthesized Compounds were examined their potent antifungal activity using disc diffusion technique against three fungal pathogens viz Aspergillus niger, Candida albicans and Curvularia. Fluconazole were used as standard drug respectively. All compounds exhibited good to moderate activity.