Aisyah, Lilis Siti; Yun, Yenny Febriany; Julaeha, Euis; Herlina, Tati; Zainuddin, Achmad; Hermawan, Wawan; Supratman, Unang; Hayashi, Hideo

Flavonoids from the Fresh Leaves of Kalanchoe tomentosa (Crassulaceae)

Lilis Siti Aisyah¹, Yenny Febriany Yun¹, Euis Julaeha¹, Tati Herlina¹, Achmad Zainuddin¹, Wawan Hermawan², Unang Supratman^{1, *}, Hideo Hayashi³

¹ Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Jatinangor 45363, Sumedang, Indonesia;

² Department of Biology, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Jatinangor 45363, Sumedang, Indonesia;

³ Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Gakuen-cho, Sakai, Osaka 599-8531, Japan

Article Information

Identifiers and Pagination:

Year: 2015
Volume: 2
First Page: 36
Last Page: 39
Publisher Id: CHEM-2-36
DOI: 10.2174/1874842201502010036

Article History:

Received Date: 28/2/2015
Revision Received Date: 11/8/2015
Acceptance Date: 16/9/2015
Electronic publication date: 13/11/2015

© Aisyah et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the (https://creativecommons.org/licenses/by/4.0/legalcode), which permits unrestricted, noncommercial use, distribution and reproduction in any medium, provided the work is properly cited.

^* Address correspondence to this author at the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Jl. Raya Bandung-Sumedang Km 21, Jatinangor 45363, Sumedang, West Java, Indonesia; Tel/Fax: +62-22-7794391; E-mail: u_supratman@unpad.ac.id

Flavonoids compounds such as kaempferol (1), kaempferol-3-O-β-D-glucopyranoside or astragalin (2) and kaempferol-3-O-α-L-rhamnoside or afzelin (3) have been isolated from the fresh leaves of Kalanchoe tomentosa (Crassulaceae). The chemical structure of isolated compounds 1-3 were identified by spectroscopic evidences and comparison with those compound previously reported. Compounds 1-3 showed cytotoxic activity against P-388 murine leukimia cells with IC₅₀ values of 51.8, > 100 and 3.32 µg/mL, respectively.

Keywords: Crassulaceae, cytotoxic activity, flavonoids, Kalanchoe tomentosa, P-388 murine leukimia cells.

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RESEARCH ARTICLE

Flavonoids from the Fresh Leaves of Kalanchoe tomentosa (Crassulaceae)

Article Information

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