Flavonoids from the Fresh Leaves of Kalanchoe tomentosa (Crassulaceae)



Lilis Siti Aisyah1, Yenny Febriany Yun1, Euis Julaeha1, Tati Herlina1, Achmad Zainuddin1, Wawan Hermawan2, Unang Supratman1, *, Hideo Hayashi3
1 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Jatinangor 45363, Sumedang, Indonesia;
2 Department of Biology, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Jatinangor 45363, Sumedang, Indonesia;
3 Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Gakuen-cho, Sakai, Osaka 599-8531, Japan


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© Aisyah et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the (https://creativecommons.org/licenses/by/4.0/legalcode), which permits unrestricted, noncommercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Jl. Raya Bandung-Sumedang Km 21, Jatinangor 45363, Sumedang, West Java, Indonesia; Tel/Fax: +62-22-7794391; E-mail: u_supratman@unpad.ac.id


Abstract

Flavonoids compounds such as kaempferol (1), kaempferol-3-O-β-D-glucopyranoside or astragalin (2) and kaempferol-3-O-α-L-rhamnoside or afzelin (3) have been isolated from the fresh leaves of Kalanchoe tomentosa (Crassulaceae). The chemical structure of isolated compounds 1-3 were identified by spectroscopic evidences and comparison with those compound previously reported. Compounds 1-3 showed cytotoxic activity against P-388 murine leukimia cells with IC50 values of 51.8, > 100 and 3.32 µg/mL, respectively.

Keywords: Crassulaceae, cytotoxic activity, flavonoids, Kalanchoe tomentosa, P-388 murine leukimia cells.