Synthesis & Antifungal Screening of Novel Azetidin-2-ones



Apoorva Gupta*, Anand K. Halve
School of Studies in chemistry, Jiwaji University Gwalior-474011, India


Article Metrics

CrossRef Citations:
2
Total Statistics:

Full-Text HTML Views: 371
Abstract HTML Views: 254
PDF Downloads: 123
ePub Downloads: 63
Total Views/Downloads: 811
Unique Statistics:

Full-Text HTML Views: 257
Abstract HTML Views: 117
PDF Downloads: 88
ePub Downloads: 41
Total Views/Downloads: 503



© Gupta and Halve; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the School of Studies in Chemistry, Jiwaji University Gwalior-474011, India; Tel: 8305962885; E-mail: apoorva.phd12@gmail.com


Abstract

A new series of 4-[3-chloro-2-(4-hydroxy-3-methoxybenzyllidene)-4-oxoazetidin-1-yl]amino-N-(substituted)benzenesulfonamide, 4-{3-chloro-2-[5-methoxy-2-nitro-4-(prop-2-en-1-yloxy)benz yllidene]-4-oxoazetidin-1-yl}]amino}-N-(substituted)benzenesulfonamide and 4-{3-chloro-2-[4-hydroxy-3-methoxy-5-(prop-2-en-1-yl)benzylidene]-4-oxoazetidin-1-yl}amino}-N-(substituted) benzenesulfonamide were synthesized using appropriate synthetic route. The chemical structures of all the synthesized compounds were deduced on the basis of elemental analysis and spectroscopic data. The antifungal activity of the synthesized compounds was screened against several fungus. The synthesized compounds show potent antifungal activity against Aspergillus niger & Aspergillus flavus and significant structure-activity relationship (SAR) trends.

Keywords: Aspergillus flavus, Azetidin-2-ones, SAR.